Title | The bone marrow protects and optimizes immunological memory during dietary restriction |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Collins N, Han S-J, Enamorado M, Link VM, Huang B, E Moseman A, Kishton RJ, Shannon JP, Dixit D, Schwab SR, Hickman HD, Restifo NP, McGavern DB, Schwartzberg PL, Belkaid Y |
Journal | Cell |
Volume | 178 |
Issue | 5 |
Date Published | 08/2019 |
Abstract | Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation. This response was coordinated by glucocorticoids and associated with a profound remodeling of the BM compartment, which included an increase in T cell homing factors, erythropoiesis, and adipogenesis. Adipocytes, as well as CXCR4-CXCL12 and S1P-S1P1R interactions, contributed to enhanced T cell accumulation in BM during DR. Memory T cell homing to BM during DR was associated with enhanced protection against infections and tumors. Together, this work uncovers a fundamental host strategy to sustain and optimize immunological memory during nutritional challenges that involved a temporal and spatial reorganization of the memory pool within “safe haven” compartments. |
URL | https://www.sciencedirect.com/science/article/pii/S0092867419308499 |
DOI | 10.1016/j.cell.2019.07.049 |